Last edited by Grozuru
Monday, May 11, 2020 | History

2 edition of Blood Perfusion and Microenvironment of Human Tumors found in the catalog.

Blood Perfusion and Microenvironment of Human Tumors

Implications for Clinical Radiooncology (Medical Radiology / Radiation Oncology)

  • 231 Want to read
  • 0 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Oncology,
  • Radiology,
  • Medical / Nursing,
  • Medical,
  • Pathophysiology,
  • Blutfluß und p02,
  • Medical / Radiology & Nuclear Medicine,
  • Mikromilieu,
  • Prognoseparameter,
  • blood flow and p02,
  • malignant tumors,
  • maligner Tumor,
  • micromilieu,
  • prognostic parameter,
  • Allied Health Services - Radiologic & Ultrasound Technology

  • Edition Notes

    ContributionsM. Molls (Editor), P. Vaupel (Editor)
    The Physical Object
    FormatPaperback
    Number of Pages248
    ID Numbers
    Open LibraryOL9695694M
    ISBN 103540669949
    ISBN 109783540669944

    The results can be seen in Table 1. 5 Blood Perfusion Parameter Estimation in Tumors by means of a Genetic AlgorithmMelo, Loureiro and Loureiro Selection Strategy Tissue Estimated blood Objective method perfusion (s−1) function Proportional Equal Parents Healthy x 10−3 Carcinogenic Proportional Different Cited by: 8.   The Tumor Microenvironment in RCC? Isaac Witz, M.D. Report. Browse more videos. Playing next. Read Tumor Blood Supply and Metabolic Microenvironment: Characterization and Implications for. Wivut. Read Blood Perfusion and Microenvironment of Human Tumors: Implications for Clinical Radiooncology. Xozevuxa. Trending. Emmanuel Macron.

      Researchers have investigated the acidity in solid tumors to determine if pH levels play a role in cancer cell invasion in surrounding tissues. They .   The CSF-1/R axis is often upregulated in human tumors and associated with poor outcome. 5 Clinical data indicate that high CSF-1/R + myeloid cell presence as compared with CD8 + T cells, and lower proportions of DCs in the TME are associated with poor clinical responses to cytotoxic therapy and reduced overall survival. 5,15 Indeed, preclinical Cited by: 8.

      Human and rodent solid tumors often exhibit elevated interstitial fluid pressure (IFP). This condition is recognized as a prognostic indicator for reduced responses to therapy and decreased disease-free survival rate. In the present study, we tested whether induction of a thermoregulatory-mediated increase in tissue blood flow, induced by exposure of mice to mild environmental heat stress Cited by:   The desmoplastic structure of the tumor and the immunosuppressive tumor microenvironment usually account for the reduced efficacy of CAR T cells in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure, increases blood perfusion, releases antigens, and promotes the recruitment of endogenous Cited by:


Share this book
You might also like
On doing local history

On doing local history

Payment of rent to Hon. J. W. Harreld. Letter from the Secretary of the Treasury, transmitting copy of a communication from the Secretary of Agriculture, submitting a proposed paragraph of legislation authorizing payment from existing appropriations to Hon. J. W. Harreld, being unpaid rent due him by the Department of Agriculture, but withheld under section 114 of the Penal Code.

Payment of rent to Hon. J. W. Harreld. Letter from the Secretary of the Treasury, transmitting copy of a communication from the Secretary of Agriculture, submitting a proposed paragraph of legislation authorizing payment from existing appropriations to Hon. J. W. Harreld, being unpaid rent due him by the Department of Agriculture, but withheld under section 114 of the Penal Code.

Rail routes in Devon & Cornwall

Rail routes in Devon & Cornwall

Estelle Doheny Collection from St. Marys of the Barrens, Perryville, Missouri, fine printed books and manuscripts, Friday, 14 December 2001.

Estelle Doheny Collection from St. Marys of the Barrens, Perryville, Missouri, fine printed books and manuscripts, Friday, 14 December 2001.

The little red bus and other rhyming stories.

The little red bus and other rhyming stories.

Mr. Bayards motion

Mr. Bayards motion

economics of tube well irrigation.

economics of tube well irrigation.

Rethinking fairness

Rethinking fairness

The sea wall

The sea wall

Efficient separations & processing crosscutting program

Efficient separations & processing crosscutting program

The quest for perfection

The quest for perfection

constitutional position of the Communist Party and the distinctiveness of the legal order in the former Soviet Union

constitutional position of the Communist Party and the distinctiveness of the legal order in the former Soviet Union

Premier Performance

Premier Performance

Environmental and economic conflict

Environmental and economic conflict

Apple® II Instant Pascal® language reference manual.

Apple® II Instant Pascal® language reference manual.

Blood Perfusion and Microenvironment of Human Tumors Download PDF EPUB FB2

This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the Format: Hardcover. Blood Perfusion and Microenvironment of Human Tumors: Implications for Clinical Radiooncology (Medical Radiology) [M.

Molls, P. Vaupel] on *FREE* shipping on qualifying offers. This book summarizes current knowledge on blood perfusion and the microenvironment of human tumors, enabling the reader to gain a deeper insight into the physiological components of malignant tumors.

Blood perfusion and microenvironment of human tumors: implications for clinical radiooncology. Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of therapeutics and cytotoxic immune cells to tumors and also results in hypoxia—a hallmark of the abnormal tumor microenvironment (TME)—that causes immunosuppression.

[CANCER RESEA July | Blood Flow, Metabolism, Cellular Microenvironment, and Growth Rate of Human Tumor Xenografts1 F. Kallinowski,2 K. Tumor blood vessels are generally poorly differentiated, unevenly spaced, and often unequal to the task of supporting the growth and even the life of rapidly metabolizing tumor cells.

16 The result is irregular blood flow, uneven perfusion, shifting zones of anoxia, low pH, and, commonly, necrosis and apoptosis. 17 In fact, the presence of Cited by: 5.

Molls M, Feldmann HJ: Clinical investigation on blood flow in malignant tumors of the pelvis and abdomen, in Vaupel P and Jain RK (eds.): Tumor Blood Supply and Metabolic Microenvironment: Characterization and Implications for Therapy, Stuggart, Fischer Verlag,in by: 3.

Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply and metabolic microenvironment of human tumors, a review.

Cancer Res ; – PubMed Google ScholarCited by: 1. A noninvasive method to obtain high-resolution images of tumor blood perfusion is needed for individualized cancer treatments. In this study we investigated the potential usefulness of dynamic contrast-enhanced MRI (DCE-MRI), using human melanoma xenografts as models of human by: The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies.

The unique properties of this organ require a specific framework for designing TME-targeted interventions. Here, we discuss a number of these distinct features, including brain-resident cell types, the blood-brain barrier, and various aspects of the Cited by: Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass.

Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system.

The latter can lead to tumor progression and may Cited by: Solid tumors have a more acidic and hypoxic microenvironment than normal tissue. This unfavorable microenvironment results from an imbalance in the oxygen supply and demand of the tumor tissue.

In fact, patients whose blood vessels normalized the most had the highest progression-free and overall survival (OS) rates (Data Supplement Fig S7).

86 But the most compelling support for the role of vascular normalization came when we looked at the blood perfusion changes in tumors. Anti-VEGF therapy actually increased tumor perfusion in some Cited by: To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations.

Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the Cited by: 1.

The Intratumor heterogeneity in the blood supply differed slightly between the A and R tumors, and even this difference was mirrored by the EF images.

Conclusion: EF images of xenografted tumors reflect blood perfusion. This implies that EF may be a useful parameter for Improving cancer diagnostics and individualizing cancer by: @article{osti_, title = {Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy}, author = {Griffin, Robert J.

and Williams, Brent W. and Park, Heon Joo and Department of Microbiology, College of Medicine, Inha University, Inchon and Song, Chang W.}, abstractNote = {Purpose: To investigate the effect of arsenic trioxide, Trisenox (TNX), on Author: Griffin, Robert J.

flow. In chemotherapy and immunotherapy, blood flow plays an important role in the delivery of appropriate pharmacologi cal agents. Finally, in hyperthermia, the temperature distribu tion and interstitial microenvironment in tumors are influenced by the local perfusion rates.

Flow rate of blood, Q, in any tissue, whether normal or neoplastic Cited by: The tumor’s local milieu is so complex, however, it remains a major roadblock standing in the way of applying immunotherapies’ early successes in blood cancers to solid tumors like breast, lung, colon, liver and pancreatic cancers, which are the top five deadliest cancers.

Metastatic tumor blood perfusion and interstitial fluid transport based on 3D microvasculature response to inhibitory effect of angiostatin are investigated. 3D blood flow, interstitial fluid transport, and transvascular flow are described by the extended Poiseuille’s, Darcy’s, and Starling’s law, respectively.

The simulation results demonstrate that angiostatin has the capacity to Author: Gaiping Zhao. (, August 12). Blood vessel 'doorway' lets breast cancer cells spread through blood stream: Investigators build upon their tumor microenvironment research. ScienceDaily. Retrieved April. The knowledge related to angiogenesis has grown exponentially over the past few decades with the recognition that angiogenesis is essential for numerous normal and pathological processes.

Very importantly, angiogenesis is required for the growth and metastasis of solid tumors in human beyond the size of 1–2 mm³ (Arap et al. ; Folkman).Author: Appu Rathinavelu.Role of the microenvironment in human iPS and NSC fate and tumorigenesis Public Abstract: Multipotent Neural Stem Cells (NSC) can be derived from adult central nervous system (CNS) tissue, embryonic stem cells (ESC), or iPSC and provide a partially committed cell population that has not exhibited evidence of tumorigenesis after long term CNS.

Abstract. Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of therapeutics and cytotoxic immune cells to tumors and also results in hypoxia—a hallmark of the abnormal tumor microenvironment (TME)—that causes by: 1.