2 edition of Recombinant immunotargeting antigen-antibody fusions in vaccine design. found in the catalog.
Recombinant immunotargeting antigen-antibody fusions in vaccine design.
Jeremy K. Cook
Written in English
|The Physical Object|
|Number of Pages||166|
The hepatitis C virus (HCV) causes both acute and chronic infection and continues to be a global problem despite advances in antiviral therapeutics. Current treatments fail to prevent reinfection and remain Cited by: 1. The fusion protein of respiratory syncytial virus (R SV F) is a major target of structure-based vaccine design. The F glycoprotein adopts two conformations: pre -fusion and post-fusion, both are.
PanBlok H7 is a pandemic influenza vaccine produced by PSC in the same way as Flublok but it is directed against H7 rather than seasonal influenza virus strains. The vaccine candidate consists of a full-length recombinant . Kwong and Mascola review vaccine approaches to overcome the formidable challenge of eliciting effective antibodies against HIV The structural and immunological information provided by analysis of infection-elicited broadly neutralizing antibodies provides a framework for antibody-to-vaccine approaches of vaccine by:
Engerix-B® (Hep-B[Eng]) is a noninfectious recombinant DNA vaccine containing hepatitis B surface antigen (HBsAg). It is produced from genetically engineered yeast Cited by: An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria .
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Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs).
Twenty-five articles by experienced and innovative authors cover examples of recombinant antibodies being used in the clinic or in development. This book Format: Hardcover. U T T E R W O R T H Vaccine, Vol. 13, No. 18, pp.E I N E M A N N Elsevier Science Ltd Printed in Great Britain X(95) oxi95 $10+ Recombinant antibodies Cited by: This immunization strategy is known as immunotargeting,, and has been reviewed elsewhere.
Of particular significance to HIV-1 vaccine development is the observation that both Cited by: Enhanced IL-2 production of human T cells by immunotargeted recombinant peptide vaccines. PBMC (2 10 5) were cultured for 7 days in the absence or presence of the antigens indicated.
In this report, we document the enhanced antibody response obtained against two recombinant subunit vaccines by means of targeting to antigen-presenting cells by a recombinant single chain antibody. Cited by: Edibility: for certain recombinant proteins, such as vaccines and antibodies, it may be advantageous to use edible plant organs as the production vehicle (e.g.
tomato fruits, potato tubers) as this allows Cited by: These vaccines utilize the L1 recombinant capsid protein of the virus subtype produced either in insect or yeast-expression system. Prokaryotic expression systems for vaccine antigen production. B-cell–lineage vaccine design requires the inference of unmutated ancestor antibodies and their intermediates from the V(D)J sequences of clonally related, mutated antibodies, as depicted Cited by: Innovative vaccine platforms are needed to develop effective countermeasures against emerging and re-emerging diseases.
These platforms should direct antigen internalization by antigen Cited by: Peptide Libraries. With more than 25 years of experience, Antibody Design Labs is a leading service provider in peptide phage libraries.
We build and screen customized libraries as a service and offer. The antibody response to hepatitis B surface antigen (anti-HBs) induced in 25 recipients of a recombinant hepatitis B vaccine derived from yeast was compared with that induced in 25 recipients of a vaccine prepared from hepatitis B surface antigen Cited by: The application of structural insight to vaccine design is especially important for new vaccines against viral pathogens.
The greater number of protective determinants of bacteria, fungi, and parasites make them suitable for a reverse vaccinology approach to discovering protective determinants with favorable vaccine Cited by: E-Mail Address. Password. Forgotten Password. Remember Me. To increase the inherently weak immunogenicity of synthetic peptide vaccines, we used recombinant DNA techniques to generate chimeras between immunogenic determinants of human immunodeficiency virus type 1 (HIV-1) gp and antibody Fab fragments reactive with surface structures displayed specifically on human antigen-presenting cells (APCs), including surface immunoglobulin Cited by: Most vaccine antigens including recombinant protein-based vaccine antigens or plasmid-based vaccine antigens elicit only a weak immunogenic response when administered alone.
The immunogenicity of these antigens can be increased by their association with an adjuvant. The antibody response to hepatitis B surface antigen (anti-HBs) induced in 25 recipients of a recombinant hepatitis B vaccine derived from yeast was compared with that induced in 25 recipients of a vaccine Cited by: We have developed an efficient versatile in vivo dendritic cell (DC) targeting vector for delivering different classes of antigens such as proteins, peptide, glycolipids and naked DNA for vaccine Cited by: Vaccine-induced, antibody-mediated protection against influenza is well characterized, but CD8 + T cells are also important.
DNA vaccines allow the induction of strong cellular responses, and the use of different targeting modules allows us to compare the relative contributions of different effectors. We compared the response to immunization using a DNA vaccine encoding dimeric APC-targeted antigen alone or in combination with protein by: 9.
Recombinant or purified protein vaccines consist of protein antigens that have either been produced in a heterologous expression system (e.g., bacteria or yeast) or purified from large amounts of the.
Recombinant protein-based anti-infectious subunit vaccines are attractive alternatives to conventional vaccines produced by inactivation or attenuation of pathogenic organisms, because Cited by:.
Protein microarrays have been developed to study antibody reactivity against a large number of antigens, demonstrating extensive perspective for clinical application.
We developed a viral antigen array by spotting four recombinant .We have developed an efficient versatile in vivo dendritic cell (DC) targeting vector for delivering different classes of antigens such as proteins, peptide, glycolipids and naked DNA for vaccine applications.
A Cited by: Vaccines are being designed to stimulate innate immune responses, as well as adaptive. Attempts are being made to develop vaccines to help cure chronic infections, as opposed to preventing disease.
Vaccines MeSH: D